1.
Bioorg Med Chem Lett
; 21(8): 2497-501, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21398125
RESUMO
Antagonism of the adenosine A(2A) receptor affords a possible treatment of Parkinson's disease. In the course of investigating pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A(2A) antagonists, we prepared [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones with potent and selective (vs A(1)) A(2A) antagonist activity. Structure-activity relationships are described for this series.